Bruker Lunch and Learn: "Exploring Ultra High Sensitivity 4D-Proteomics in Single Cells"

Single cell proteomics is a young niche of proteomics compared to single cell genomics. In recent years, significant progress has been made in sample handling and dispensing, boosting the sample signal by multiplexing. The timsTOF SCP is the first commercially introduced mass spectrometer dedicated for single cell proteomics driven by a 4-5 fold boost in sensitivity. The modified front-end with complimentary ion-guide advancements helps increase sensitivity and preserves the robustness – the default attribute of the timsTOF platform. This combined with advantages in bioinformatics and single cell delivery make single cell proteomics a reality. In addition to Single Cell Proteomics, timsTOF SCP enables High Throughput Ultra High Sensitive workflows for immunoproteomics and clinical samples, especially where sample amounts are limited a reality.